Assistant Professor of Biology
- Office: Olmsted Hall of Biological Sc
- Phone: 437-7928
- Box: 70
- Email: email@example.com
- Postdoctoral Fellow, 2013 - 2016, Lifespan Cardiovascular Institute, Providence, RI, and Cardiovascular Engineering, Inc., Norwood, MA
- M.P.H., 2016, Quantitative Methods, Harvard University, T. H. Chan School of Public Health, Boston, MA
- Ph.D., 2013, Molecular Pharmacology and Physiology, Brown University, Providence, RI
- B.S., 2005, Biochemistry and Sociology, Clemson University, Clemson, SC
Cardiovascular Physiology and Epidemiology; Vascular Stiffness; Microvascular Function; Cerebrovascular Disease; Aging; Health Disparities; and Cardiac Electrophysiology and Arrhythmia
Summary: Cardiovascular disease (CVD) is the leading cause of death in the United States. Increased arterial stiffening and abnormal vascular hemodynamics with advancing age are associated with increased CVD related events including death. In light of a rapid aging of the world population, the burden of CVD, and its associated disorders, will increase substantially over the next years. As such, novel therapeutic and preventative measures are necessary to limit or reduce aortic stiffening with advancing age. Using a population-based approach, my research seeks to examine the associations of vascular hemodynamic load with CVD in order to elucidate potential targets for treatment and prevention.
Physiology; Public Health; Epidemiology; Cardiovascular Physiology; and Cell and Molecular Physiology
Courses: BIOL 106 Introduction to Biological Investigation; BIOL 288 Epidemiology; BIOL 389 Cardiovascular Physiology and Epidemiology; and STS 268 Current and Emerging Issues in Public Health
- Cooper LL, Himali JJ, Torjesen A, Tsao CW, Beiser A, Hamburg NM, DeCarli C, Vasan RS, Seshadri S, Pase MP, and Mitchell GF. (2017). Inter-relations of orthostatic blood pressure change, aortic stiffness, and brain structure and function in young adults. J Am Heart Assoc. 6(8):e006206. [PMID: 28862943]
- Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, Levy D, Benjamin EJ, Vasan RS, and Mitchell GF. (2017). Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults: the Framingham Heart Study. Hypertension. 69(4):685-690. [PMID: 28264924].
- Cooper LL, Palmisano JN, Benjamin EJ, Larson MG, Levy D, Vasan RS, Mitchell GF, and Hamburg NM. (2016). Microvascular function mediates relations between aortic stiffness and cardiovascular events. Circ Cardiovasc Imaging. 9(12):e004979. [PMID: 27956408].
- Cooper LL and Mitchell GF. (2016). Aortic stiffness, cerebrovascular dysfunction, and memory: a mini-review. Pulse (Basel). 4(2-3):69-77. Review. [PMID: 27752478].
- Cooper LL, Woodard T, Sigurdsson S, van Buchem MA, Torjesen AA, Levey AS, Inker LA, Aspelund T, Eiriksdottir E, Harris TB, Gudnason V, Launer LJ, and Mitchell GF. (2016). Cerebrovascular damage mediates relations between aortic stiffness and memory. Hypertension. 67:176-182. [PMID: 26573713].
- Cooper LL, Rong J, Benjamin EJ, Larson MG, Levy DL, Vita JA, Hamburg NM, Vasan RS, and Mitchell GF. (2015). Components of hemodynamic load and cardiovascular events: The Framingham Heart Study. Circulation. 131(4):354-361. [PMID: 25416177].
- Beane O, Fonseca VC, Cooper LL, Koren G, and Darling EM. (2014). Impact of aging on the therapeutic potential of bone marrow-, muscle-, and adipose-derived mesenchymal stem cells. PLOS ONE. 9(12):e115963. [PMID: 25541697].
- Moshal K, Zheng Z, Roder K, Kim T, Cooper LL, Litvinov BP, Lu Y, Reddy V, Terentyev D, Choi B, and Koren G. (2014). Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes. Am J Physiol Cell Physiol. 07(11):C1050-1057. [PMID: 25252951].
- Terentyev D, Rees C, Li W, Cooper LL, Jindal HK, Peng X, Lu Y, Terentyeva R, Odening KE, Daley J, Bist K, Choi B, Karma A, and Koren G. (2014). Hyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome. Cir Res. 115(11):919-928. [PMID: 25249569].
- Cooper LL, Li W, Lu YC, Centracchio J, Terentyeva R, Koren G, and Terentyev D. (2013). Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts. J Physiol. 591(23):5895-5911. [PMID: 24042501].
- Cooper LL, Odening KE, Hwang M, Chaves L, Schofield L, Taylor CA, Gemignani AS, Mitchell GF, Forder JR, Choi B, and Koren G. (2012). Electromechanical and structural alterations in the aging rabbit heart and aorta. Am J Physiol Heart Circ Physiol. 302(8):H1625–H1635. [PMID: 22307668].
- Meng Y, Ingram-Smith C, Cooper LL, and Smith KS. (2010). Characterization of an archaeal medium-chain acyl-CoA synthetase from Methanosarcina acetivorans. J Bacteriol. 192(22):5982–5990. [PMID: 20851904].
- Shah MB, Ingram-Smith C, Cooper LL, Ou J, Meng Y, Smith KS, and Gulick AM. (2009). The 2.1Å crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl binding pocket for small branched acyl substrates. Proteins. 77(3):685–698. [PMID: 19544569].